Gluconeogenesis primarily occurs in which organ?

Gluconeogenesis is a metabolic process through which glucose is synthesized from non-carbohydrate precursors, and this process primarily occurs in the liver. The liver plays a central role in maintaining glucose homeostasis, especially during fasting or strenuous exercise when glucose levels in the blood may drop.

In the liver, gluconeogenesis is particularly active, utilizing substrates such as lactate, glycerol, and amino acids to generate glucose. This newly synthesized glucose is then released into the bloodstream to provide energy to various tissues and maintain blood glucose levels. While the kidneys also participate in gluconeogenesis, especially during prolonged fasting, their contribution is significantly less compared to that of the liver. The heart and pancreas do not play a primary role in this metabolic pathway. Thus, the liver is the key organ responsible for gluconeogenesis, making the answer accurate.