Osteogenesis imperfecta and Ehlers-Danlos syndrome primarily target which type of collagen?

Osteogenesis imperfecta (OI) is a genetic disorder characterized by fragile bones that break easily, often with little or no apparent cause. This condition is primarily due to mutations in the genes responsible for collagen type 1, which is the most abundant type of collagen found in bones, tendons, and other connective tissues. The impaired production of type 1 collagen leads to the characteristic symptoms of OI.

Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders that can also be linked to abnormalities in collagen. The classic types of EDS are often associated with defects in type 1 collagen; however, some forms of EDS can also involve other types of collagen, like type 3, which is significant in blood vessels and skin. Nevertheless, type 1 collagen remains a common factor in many manifestations of EDS.

Therefore, both osteogenesis imperfecta and Ehlers-Danlos syndrome primarily target type 1 collagen, making this the correct answer.