What condition is associated with Wilson's disease?

Wilson's disease is a genetic disorder that leads to excessive copper accumulation in the body, primarily affecting the liver and the brain, which is why it is commonly referred to as hepatolenticular disease. The term “hepatolenticular” reflects the dual impact on the liver (hepato) and the basal ganglia in the brain (lenticular). This disease manifests through a range of symptoms, including liver dysfunction, neurological issues, and psychiatric problems due to the accumulation of copper.

In addition to hepatolenticular disease, Wilson's disease can also result in the formation of Fleischer rings, which are deposits of copper seen in the corneas, but the primary association is with the dysregulation of copper metabolism leading to damage in both the liver and the central nervous system. The identification of Wilson's disease often involves recognizing these key features and understanding the pathology behind copper accumulation.

Other conditions such as hyperthyroidism or vitamin A deficiency do not directly relate to the characteristic pathology of Wilson’s disease. The specifics of hepatolenticular disease encompass the critical aspects of how this condition affects the body and highlight its clinical importance.