What is the main type of collagen found in Descemet's membrane?

Descemet's membrane, a specialized component of the cornea, primarily consists of Type 4 collagen. This type of collagen is uniquely structured to form a mesh-like network, which contributes to the strength and stability of the basement membranes found in various tissues, including the cornea.

Type 4 collagen plays a critical role in maintaining the integrity and function of Descemet's membrane by providing a supportive framework that helps in anchoring the endothelial cells to the underlying stroma. Unlike the other types of collagen, which are typically found in other connective tissues (like Type 1 in skin and bone, Type 2 in cartilage, and Type 3 in reticular fibers), Type 4 is specifically suited for its function in basement membranes, offering unique properties such as filtration and support to overlying cells.

In summary, Type 4 collagen's specific structural and functional characteristics make it the primary collagen found in Descemet's membrane, which is essential for maintaining corneal transparency and overall ocular health.