Which two organs are primarily involved in glycogenolysis?

The liver and muscles are the primary organs involved in glycogenolysis. Glycogenolysis is the biochemical process that breaks down glycogen into glucose-1-phosphate, which can then be used for energy.

The liver plays a crucial role in maintaining blood glucose levels, especially during fasting or between meals. It stores glycogen and, when energy is needed, can quickly mobilize glucose into the bloodstream to provide energy for other tissues.

Muscles also store glycogen, which they use as a readily available source of energy during physical activity. However, the glucose released from muscle glycogen is primarily utilized locally within the muscle tissue and is not released back into the bloodstream.

Thus, the involvement of both the liver and muscles is vital in the regulation and supply of glucose derived from glycogen stores, making them the key organs in glycogenolysis.